The Occupational Health Program is designed to inform individuals who work with animals about potential zoonoses (diseases of animals transmissible to humans), personal hygiene, and other potential hazards associated with animal exposure. This information sheet is directed toward those involved in the care and use of wild rodents and rabbits.
Wild rodents and rabbits may inflict injury such as a bite or scratch. Employees need to receive training on the correct way to capture and handle any wild animals. While they may carry or shed organisms that may be potentially infectious to humans, the primary health risk to individuals working with captured animals is the development of an allergy. The development of disease in the human host often requires a preexisting state that compromises the immune system. If you have an immune-compromising medical condition or you are taking medications that impair your immune system (steroids, immunosuppressive drugs, or chemotherapy) you are at higher risk for contracting a rodent disease and should consult your physician. The following is a list of some of the potential wild rodents and rabbits.
Rabies: Rabies virus (rhabdovirus) can infect almost any mammal. The source of infection to people is an infected animal. The virus is shed in the animal's saliva 1-14 days before developing clinical signs. Any random-source (animal with an unknown clinical history) or wild animal exhibiting central nervous system signs that are progressive should be considered suspect for rabies. Transmission is through contact with saliva, mucus membranes, or blood, e.g. bite, or saliva on an open wound. Symptoms are pain at the site of the bite followed by numbness. The skin becomes quite sensitive to temperature changes and there are laryngeal (throat) spasms. Muscle spasms and extreme excitability are present and convulsions occur. Rabies in unvaccinated people is almost invariably fatal. Rabies vaccine is available through Occupational Health at Student Health Services.
Lymphocytic choriomeningitis: Lymphocytic choriomeningitis (LCM) is caused by the arenavirus commonly associated with hamsters, but does infect mice. LCM is rare in laboratory animal facilities, more common in the wild. Transmission to humans is through contact with tissues including tumor, feces, urine, or aerosolization of any one of these. Disease in humans is generally flu-like symptoms that range from mild to severe.
Campylobacter: This is a gram negative bacterium that has a worldwide distribution. Although most cases of human campylobacteriosis are of unknown origin, transmission is thought to occur by the fecal-oral route, through contamination of food or water, or by direct contact with infected fecal material. The organism has also been isolated from houseflies. Campylobacter is shed in the feces for at least six weeks after infection. Symptoms are acute gastrointestinal illness: diarrhea with or without blood, abdominal pain, and fever. It may cause pseudoappendicitis and, rarely, septicemia and arthritis. Usually it is a brief self-limiting disease that can be treated with antibiotics.
Leptospirosis: Is bacteria found in many animals but are most commonly associated with livestock and dogs. The source of infection can be from any of the following: rats, mice, voles, hedgehogs, gerbils, squirrels, rabbits, hamsters, reptiles, dogs, sheep, goats, horses, standing water. Leptospires are in the urine of infected animals and are transmitted through direct contact with urine or tissues via skin abrasions or contact with mucous membranes. Transmission can also occur through inhalation of infectious droplet aerosols and by ingestion. The disease in people is multi-systemic disease with chronic sequelae. An annular rash is often present with flu like symptoms. Cardiac and neurological disorders may follow and arthritis is a common end result.
Hantavirus infection: Hantavirus occurs mainly among the wild rodent populations. Rats and mice have been implicated in outbreaks of the disease. Rodents shed the virus in their respiratory secretions, saliva, urine and feces. Transmission to humans is via inhalation of infectious aerosols. The disease is characterized by fever, headache, myalgia (muscle aches) and petechiae (rash) and other hemorrhagic symptoms including anemia and gastrointestinal bleeding.
By far the greatest occupational risk to working with rodents and rabbits is allergic reaction or developing allergies. Those workers that have other allergies are at greater risk. Animal or animal products such as dander, hair, scales, fur, saliva and body waste, and urine in particular, contain powerful allergens that can cause both skin disorders and respiratory symptoms. The primary symptoms of an allergic reaction are nasal or eye symptoms, skin disorders, and asthma.